USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P04350 USC-OGP 2-DE database:  P04350 P04350 General information about the entry View entry in simple text format Entry name TBB4A_HUMAN Primary accession number P04350 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Tubulin beta-4A chain; AltName: Full=Tubulin 5 beta; AltName: Full=Tubulin beta-4 chain;. Gene name Name=TUBB4A Synonyms=TUBB4, TUBB5 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0067: pI=4.86; Mw=51629 SPOT OGP-0176: pI=4.81; Mw=27222 Cross-references UniProtKB/Swiss-Prot P04350; TBB4A_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name TBB4A_HUMAN Primary accession number P04350 Secondary accession number(s) B3KQP4 Q969E5 Sequence was last modified on  April 18, 2006 (version 2) Annotations were last modified on  March 15, 2017 (version 184) Name and origin of the protein Description RecName: Full=Tubulin beta-4A chain; AltName: Full=Tubulin 5 beta; AltName: Full=Tubulin beta-4 chain; Gene name Name=TUBB4A Synonyms=TUBB4, TUBB5 Encoded on Name=TUBB4A; Synonyms=TUBB4, TUBB5 Keywords Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Dystonia; GTP-binding; Isopeptide bond; Leukodystrophy; Microtubule; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X00734; CAA25318.1; -; Genomic_DNA EMBL AK075307; BAG52106.1; -; mRNA EMBL CH471139; EAW69078.1; -; Genomic_DNA EMBL BC006570; AAH06570.1; -; mRNA EMBL BC013683; AAH13683.1; -; mRNA CCDS CCDS12168.1; -; . PIR A02972; UBHU5B; . RefSeq NP_001276052.1; NM_001289123.1; . RefSeq NP_001276056.1; NM_001289127.1; . RefSeq NP_001276058.1; NM_001289129.1; . RefSeq NP_001276059.1; NM_001289130.1; . RefSeq NP_001276060.1; NM_001289131.1; . RefSeq NP_006078.2; NM_006087.3; . UniGene Hs.110837; -; . ProteinModelPortal P04350; -; . SMR P04350; -; . BioGrid 115655; 64; . IntAct P04350; 46; . MINT MINT-1146958; -; . STRING 9606.ENSP00000264071; -; . ChEMBL CHEMBL2095182; -; . DrugBank DB05147; CYT997; . DrugBank DB03010; Epothilone B; . DrugBank DB01873; Epothilone D; . DrugBank DB06042; ZEN-012; . iPTMnet P04350; -; . PhosphoSitePlus P04350; -; . SwissPalm P04350; -; . BioMuta TUBB4A; -; . DMDM 93141323; -; . OGP P04350; -; . REPRODUCTION-2DPAGE IPI00023598; -; . EPD P04350; -; . MaxQB P04350; -; . PaxDb P04350; -; . PeptideAtlas P04350; -; . PRIDE P04350; -; . TopDownProteomics P04350; -; . DNASU 10382; -; . Ensembl ENST00000264071; ENSP00000264071; ENSG00000104833; . GeneID 10382; -; . KEGG hsa:10382; -; . UCSC uc002mfg.2; human; . CTD 10382; -; . DisGeNET 10382; -; . GeneCards TUBB4A; -; . HGNC HGNC:20774; TUBB4A; . HPA CAB010768; -; . HPA HPA043640; -; . HPA HPA046280; -; . MalaCards TUBB4A; -; . MIM 128101; phenotype; . MIM 602662; gene; . MIM 612438; phenotype; . neXtProt NX_P04350; -; . OpenTargets ENSG00000104833; -; . Orphanet 139441; Hypomyelination with atrophy of basal ganglia and cerebellum; . Orphanet 98805; Primary dystonia; DYT4 type; . PharmGKB PA134949465; -; . eggNOG KOG1375; Eukaryota; . eggNOG COG5023; LUCA; . GeneTree ENSGT00760000119061; -; . HOGENOM HOG000165710; -; . InParanoid P04350; -; . KO K07375; -; . OMA SPFGQLF; -; . OrthoDB EOG091G06U2; -; . PhylomeDB P04350; -; . TreeFam TF300298; -; . Reactome R-HSA-1445148; Translocation of GLUT4 to the plasma membrane; . Reactome R-HSA-190840; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; . Reactome R-HSA-190861; Gap junction assembly; . Reactome R-HSA-2132295; MHC class II antigen presentation; . Reactome R-HSA-2467813; Separation of Sister Chromatids; . Reactome R-HSA-2500257; Resolution of Sister Chromatid Cohesion; . Reactome R-HSA-2565942; Regulation of PLK1 Activity at G2/M Transition; . Reactome R-HSA-380259; Loss of Nlp from mitotic centrosomes; . Reactome R-HSA-380270; Recruitment of mitotic centrosome proteins and complexes; . Reactome R-HSA-380284; Loss of proteins required for interphase microtubule organization from the centrosome; . Reactome R-HSA-380320; Recruitment of NuMA to mitotic centrosomes; . Reactome R-HSA-389957; Prefoldin mediated transfer of substrate to CCT/TriC; . Reactome R-HSA-389960; Formation of tubulin folding intermediates by CCT/TriC; . Reactome R-HSA-389977; Post-chaperonin tubulin folding pathway; . Reactome R-HSA-437239; Recycling pathway of L1; . Reactome R-HSA-5610787; Hedgehog 'off' state; . Reactome R-HSA-5617833; Cilium Assembly; . Reactome R-HSA-5620912; Anchoring of the basal body to the plasma membrane; . Reactome R-HSA-5620924; Intraflagellar transport; . Reactome R-HSA-5626467; RHO GTPases activate IQGAPs; . Reactome R-HSA-5663220; RHO GTPases Activate Formins; . Reactome R-HSA-6807878; COPI-mediated anterograde transport; . Reactome R-HSA-6811434; COPI-dependent Golgi-to-ER retrograde traffic; . Reactome R-HSA-6811436; COPI-independent Golgi-to-ER retrograde traffic; . Reactome R-HSA-68877; Mitotic Prometaphase; . Reactome R-HSA-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint; . Reactome R-HSA-8854518; AURKA Activation by TPX2; . Reactome R-HSA-983189; Kinesins; . SIGNOR P04350; -; . ChiTaRS TUBB4A; human; . GeneWiki TUBB4; -; . GenomeRNAi 10382; -; . PRO PR:P04350; -; . Proteomes UP000005640; Chromosome 19; . Bgee ENSG00000104833; -; . CleanEx HS_TUBB4; -; . ExpressionAtlas P04350; baseline and differential; . Genevisible P04350; HS; . GO GO:0005929; C:cilium; IEA:Ensembl; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0033269; C:internode region of axon; IEA:Ensembl; . GO GO:0005874; C:microtubule; IDA:UniProtKB; . GO GO:0015630; C:microtubule cytoskeleton; IDA:HPA; . GO GO:0043209; C:myelin sheath; IEA:Ensembl; . GO GO:0043025; C:neuronal cell body; IEA:Ensembl; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0005525; F:GTP binding; IEA:UniProtKB-KW; . GO GO:0003924; F:GTPase activity; IEA:InterPro; . GO GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro; . GO GO:0097711; P:ciliary basal body docking; TAS:Reactome; . GO GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome; . GO GO:0007017; P:microtubule-based process; IEA:InterPro; . Gene3D 1.10.287.600; -; 1; . Gene3D 3.30.1330.20; -; 1; . Gene3D 3.40.50.1440; -; 1; . InterPro IPR013838; Beta-tubulin_BS; . InterPro IPR002453; Beta_tubulin; . InterPro IPR008280; Tub_FtsZ_C; . InterPro IPR000217; Tubulin; . InterPro IPR018316; Tubulin/FtsZ_2-layer-sand-dom; . InterPro IPR023123; Tubulin_C; . InterPro IPR017975; Tubulin_CS; . InterPro IPR003008; Tubulin_FtsZ_GTPase; . PANTHER PTHR11588; PTHR11588; 1; . Pfam PF00091; Tubulin; 1; . Pfam PF03953; Tubulin_C; 1; . PRINTS PR01163; BETATUBULIN; . PRINTS PR01161; TUBULIN; . SMART SM00864; Tubulin; 1; . SMART SM00865; Tubulin_C; 1; . SUPFAM SSF52490; SSF52490; 1; . SUPFAM SSF55307; SSF55307; 1; . PROSITE PS00227; TUBULIN; 1; . PROSITE PS00228; TUBULIN_B_AUTOREG; 1; .

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